![]() ![]() While waiting for a large scale clinical trial where patients treated with statins are also monitored for their CoQ10 status, with a group also being given CoQ10, physicians should be aware of this drug-nutrient interaction and be vigilant to the possibility that statin drugs may, in some cases, impair skeletal muscle and myocardial bioenergetics. We can reasonably hypothesize that in some conditions where other CoQ10 depleting situations exist treatment with statins may seriously impair plasma and possible tissue levels of coenzyme Q10. Some papers indicate that CoQ10 depletion during statin therapy might be associated with subclinical cardiomyopathy and this situation is reversed upon CoQ10 treatment. And they’re typically safe and free of side effects. Should patients on statins take Coenzyme Q10 supplementation to reduce the risk of statin-induced myopathy Prepared by UK Medicines Information (UKMi). There are also some indications that statin treatment affects muscle ubiquinone levels, although it is not yet clear to which extent this depends on some effect on mitochondrial biogenesis. CoQ10 supplements may help reduce statin-related muscle pain and support overall heart health. Brian Staiger is a licensed pharmacist in New York. Most studies that show benefit using CoQ10 with Lipitor used between 100mg and 200mg per day. If you are experiencing problems with Lipitor, it is worth trying it but be sure to let your doctor know of your side effects. This could be related to the fact that statins lower plasma LDL levels, and CoQ10 is mainly transported by LDL, but a decrease is also found in platelets and in lymphocytes of statin treated patients, therefore it could truly depend on inhibition of CoQ10 synthesis. CoQ10 is well tolerated and has minimal, if any, drug interactions. Plasma levels of CoQ10 are lowered in the course of statin treatment. Study results of the benefits of CoQ10 for reducing muscle pain. Fortunately, studies suggest that supplementing with CoQ10 may help. Taking CoQ10 supplements can help increase your CoQ10 levels and may reduce statin side effects. As a result of the common biosynthetic pathway Coenzyme Q (ubiquinone) and dolichol levels are also affected, to a certain degree, by the treatment with these HMG-CoA reductase inhibitors. One reason statins increase the risk of diabetes is because they deplete the body of CoQ10. In some cases treatment with statins produces skeletal muscle complaints, and/or mild serum CK elevation the incidence of rhabdomyolysis is very low. Statins are drugs of known and undisputed efficacy in the treatment of hypercholesterolemia, usually well tolerated by most patients. ![]()
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